Molecular mechanism of an aspirin compound for alleviation of osteoporosis using nerwork pharmacology and molecular docking

The aspirin compound (AC) is commonly found to have a wide range ofpharmacological activities. This study aimed investigate the underlying mechanism ofthe anti-osteoporotic (anti-OP) activity of AC using network pharmacology and moleculardocking approaches. First, targets were identified GeneCards database, andsecond, OP-related mined combination andDisGeNet databases. intersection from Genecards, AC, OP databaseswere considered candidate utilized calculate protein-protein interactionsbetween targets. We discovered C4A target in OPdatabases. useful for molecular binding. In addition, we obtained 11 additionalprospective that may be used attach molecule these At theintersection region groups are genes HLA-DQA1, HLADQB1, RPL31, SATB2, SP1, WNT1. And at GeneCardsand databases, anti-OP CTSK, PDIA2, RARG, andTBC1D8. They crucial binding interact with other protein targets.According interaction network, showed highest bindingcapacity proteins. gene ontology (GO) analysis performed this workfound 10 biological processes, cellular components, 9 activities, 13biological pathways. Furthermore, associated withhomologous mainly involved signaling pathways Kyoto Encyclopediaof Genomics (KEGG). was highly bound to11 candidates. alleviate usingthe search interactions thetargets endorse against OP. help us understand action ofAC during treatment.